Albumin is the principal protein of the circulatory system comprising about 50% of the blood by dry weight.  It is a large protein of 585 amino acids in length (66,500 dalton) comprised of three structurally homologous domains (I, II and III).   Structurally, it is almost entirely alpha helical, forming a heart shaped molecule highly stabilized by 17 disulphide bridges.  The three main drug binding regions of albumin are located on each of the three domains within subdomains IB, IIA and IIIA.

Albumin is chiefly responsible for the maintenance of colloid osmotic blood pressure (80%), blood pH and the transport and distribution of a plethora of endogenous and exogenous ligands.  Pharmaceutically, it has been used as a volume expander since the pioneering work of Dr. Cohn at Harvard University during World War II.   This application alone represents a multibillion dollar industry, principally from albumin derived from pooled outdated human blood.

Because of albumins abundance, low cost and high purity, it has been used in a variety of research applications, making it historically one of the most highly studied and applied proteins in biochemistry.  In addition to the use as a volume expander, some of the many applications include excipients (for vaccines and other biologics), cell culture, in vitro fertilization, medical device coatings, biomaterials and diagnostics.

Mouse derived albumin is expensive, and now with recombinant availability, unnecessarily produced from the pooled blood of numerous animals.  In addition, recombinant mouse albumin (rMSA)  is generally less expensive and is produced using standards superior to animal derived materials making it more suitable for preclinical studies. There are reduced risks from animal derived viruses that might inadvertently affect your pre-clinical study.  Our rMSA has been used successfully by our customers in preclinical studies.

Albumin Bioscience ships orders within 2-3 business days from the purchase date. International orders ship within 3-5 business days. You will be contacted within 48 hours via the email address provided if your order will take longer to complete.

Recombinant Mouse Serum Albumin #2601

This is a low endotoxin recombinant mouse serum albumin. No animal derived materials are ever used in the production process and formulation. Final formulation: lyophilized in purified water with no additives.

Storage: Mouse serum albumin is more fragile than human albumin. Short term storage of lyophilized powder or dissolved material can be stored at 4 degrees Celcius. In general, and for longer term storage, this product should be stored at -80 degrees Celcius until use. Numerous freeze-thaw cycles should be avoided.

Solubility: Buffers should be added to the powder without stirring, allowing the protein to dissolve over the course of 15 to 30 minutes. This product is most soluble in water or PBS. Concentrations to 5% (50m/ml) are readily achievable.

Sterile filtration: The process for this product maintains sterility during critical stages of preparation. However, the final freeze-drying step, while handled aseptically and sealed under a sterile hood, is technically not sterile. For animal experiments, we recommend sterile filtration prior to use.

Formulation: Lyophilized in purified water with no additives.